AF Goats
Recently, we developed a novel cardiac specific hTGF-β1 transgenic goat with an underlying atrial cardiomyopathy and increased susceptibility to AF when compared to wild-type (WT) control animals.
Cystic Fibrosis Sheep
Mono and Bi-allelic knockout sheep model of Cystic Fibrosis disease. Cystic Fibrosis (CF) is a human autosomal genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene.
Human K-ras G12D Model
Human mutated K-ras (hK-rasG12D) was knocked in goat endogenous K-ras locus through homologous recombination. Human mutated K-ras (hK-rasG12D) was chosen as the transgene, as it is present in 20% of cancers.
IFNAR Knockout Sheep Model
Interferon alpha (IFNA) and interferon beta (IFNB) are type I interferons produced by cells infected with viruses. IFNA and IFNB are important for protection against viral pathogens because they trigger an innate or early response.
Nanos2 Goats
The NANOS2 gene, encoding an RNA binding protein, plays a critical role in the development of germline.